Based on the novel by Nick Hornby and the 2002 film directed by Chris and Paul Weitz, "About a Boy" will focus on self-absorbed thirtysomething (Dempsey) whose inherent faith in his own coolness is put to the test when he befriends a troubled 12-year-old boy and his equally troubled mother. According to The Hollywood Reporter, the "About a Boy" pilot was written by Matthew Carlson ("The Wonder Years"), who will also executive produce.

In addition to his work on "Once and Again," Dempsey has done guest spots on "Will & Grace." On the big screen, Dempsey has starred in "Can't Buy Me Love" and "Meatballs III." He was most recently seen opposite Reese Witherspoon in "Sweet Home Alabama."

In other casting news, at ABC, Bill Duke has joined the drama pilot "Karen Sisco." Based on the Jennifer Lopez character in Elmore Leonard and Steven Soderbergh's "Out of Sight," the show will focus on a female US marshal played by Carla Gugino. Duke has most recently been seen in "Red Dragon," "Never Again" and "Exit Wounds." He is also the director of "Deep Cover" and "Hoodlum."